GABA puts the brakes on TRPV1

At the Institute of Pharmacology, CellNetworks member and SFB1158 PI Prof. Jan Siemens and his research group explore sensory mechanisms at the molecular level. In their paper, published in Cell in 2015, they discovered a molecular mechanism in nerve cells which reverts the sensitized state of the capsaicin receptor TRPV1. With the activiation of GABAB1, the receptor forms a complex with TRPV1 to counteract inflammatory pain. Harnessing this mechanism for anti-pain therapy may prevent adverse effects associated with currently availabe TRPV1 blockers.

Find out more about the research on their lab website.

News

  • New monthly Data Seminar Series

    Data management and analysis updates, workshops & tutorials for the SFB 1158 community

    Read more ...  
  • Congratulations to Dr. Stefan Lechner!

    Co-PI of Projects A01 and A04 accepts new position in Hamburg

     

    Read more ...  
  • ECNP Neuropsychopharmacology Award

    Congratulations to Prof. Dr. Valery Grinevich (Project B02)!

     

    Read more ...  
  • Silvia King Award 2021

    Congratulations to Dr. Johann Jende (Project A03)!

     

    Read more ...  
  • SFB1158 and NIKON BioImage Analysis Workshop

    Registration deadline extended until 30 April 2021

     

    Read more ...